Coagulation factors are mostly synthesized in what part of the body?	Liver
How many coagulation factors are zymogens (inactive enzyme form)?	8
Coagulation factors that bind, stabilize, and enhance the activity of their respective zymogens are called as?	Cofactors
A crude mixture of tissue factor and phospholipid will result to?	Tissue thromboplastin
Platelet phospholipids (phosphatidylserine) were once called as?	Platelet factor 3
Serine protease procoagulants. (7)	Factor 2 Factor 7 Factor 9 Factor 10 Factor 11 Factor 12 Prekallikrein
Cofactor procoagulants (4).	Factor 3 Factor 5 Factor 8 HMWK
Coagulation factor as the only transamidase/transglutaminase.	Factor 13
The ultimate thrombin substrate of the coagulation pathway.	Fibrinogen
Known as Fibrinogen.	Factor 1
Known as Fibrin.	Factor 1a
Known as Prothrombin.	Factor 2
Known as Tissue factor.	Factor 3
Known as Ionic calcium.	Factor 4
Known as Labile factor.	Factor 5
Known as Stable factor.	Factor 7
Known as Antihemophilic factor.	Factor 8
Known as Christmas factor.	Factor 9
Known as Stuart-Prower factor.	Factor 10
Known as Plasma thromboplastin antecedent (PTA).	Factor 11
Known as Hageman factor.	Factor 12
Known as Fletcher factor.	Prekallikrein
Known as Fitzgerald factor.	High-molecular-weight kininogen (HMWK)
Known as Fibrin-stabilizing factor.	Factor 13
Required for the assembly of coagulation complexes on platelet or cell membrane phospholipids.	Calcium
What will happen in zymogen activation is uncontrolled and generalized?	DIC
The only insoluble coagulation factor.	Factor 3
What is the minimum level for most coagulation factors to achieve hemostatic effectiveness and that level must be maintained to prevent bleeding in factor-deficient patients.	25-30%
What desirable level of Antihemophilic factor must be maintained for a hemophilic patient on therapy?	Above 30%
Coagulation factor with the lowest half-life of 6 hrs.	Factor 7
Coagulation factor with the highest half-life of 156 hrs.	HMWK
Vitamin K-dependent prothrombin group.	Factor 2 Factor 7 Factor 9 Factor 10
Vitamin K-dependent regulatory proteins.	Protein C, S, Z
Vitamin K is produced by what intestinal microorganisms?	Bacteroides fragilis E. coli
Steps of Vitamin K function in coagulation.	1. Vitamin K catalyzes y-carboxylation of amino-terminal glutamic acid. 2. When a 2nd carboxyl group is added to the y carbon, glutamic acid is modified to y-carboxyglutamic acid . 3. With 2 ionized carboxyl group, y-carboxyglutamic acids gain a net (-) charge, enabling them to bind Ca²+. 4. The bound Ca²+ enables Vitamin K-dependent procoagulants to bind to (-) charged phospholipids to form coagulation complexes.
What will happen if there is a presence of warfarin as a Vitamin K antagonist?	1. Vitamin K-dependent procoagulants are released in the liver without the 2nd carboxyl group added to the gamma carbon. 2. Because they lack the 2nd carboxyl group, they cannot bind to Ca²+ & phospholipid, thus, cannot participate in the coagulation reaction.
Extrinsic tenase complex.	7a:TF:Ca²+
Intrinsic tenase complex.	9a:8a:Ca²+
Prothrombinase complex.	10a:5a:PF3:Ca²+
Vitamin K-dependent procoagulants without 2nd carboxyl group added to the y carbon are called as?	Proteins in Vitamin K Antagonism (PIVKAs)
Extrinsic tenase complex activates what coagulation factor?	Factor 9 & 10
Intrinsic tenase complex activates what coagulation factor?	Factor 10
Prothrombinase complex activates what coagulation factor?	Factor 2 (Prothrombin)
A marker for thrombin generation.	Prothrombin fragment 1.2

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